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Ayr Wellness Medical Marijuana Dispensary New Castle

Ayr Wellness New Castle

809 Sampson St
New Castle, PA 16101

(724) 652-1010 

Online Ordering Available 24/7 (In-Store Pickup)
Orders placed after 6:30pm will be available for pickup the next day

Curbside Pickup
Details coming soon!

Order Online


Hours of Operation:

  • Monday: 10:00am - 7:00pm
  • Tuesday: 1​0:00am - 7:00pm
  • Wednesday: 10:00am - 7:00pm
  • Thursday: ​10:00am - 7:00pm
  • Friday: ​10:00am - 7:00pm
  • Saturday: 1​0:00am - 7:00pm
  • Sunday: 1​0:00am - 7:00pm

We offer deals and discounts every week! Please let us know if you are a Veteran, First Responder, Senior or Industry Worker because we'd like to provide you with a special discount! 

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Ayr Wellness Medical Marijuana Dispensary New Castle

Welcome to Ayr Wellness, the best medical marijuana dispensary in New Castle! Here at Ayr Wellness, we believe in creating positive change in the lives of our patients and promoting wellness, inspiring wonder, and contributing to strong, socially responsible communities. Our medical cannabis dispensary is located at 809 Sampson St, New Castle, PA 16101, only 30 minutes outside of Youngstown, Ohio and a short car ride away from New Castle Municipal Airport.
We want you to take your time browsing our selection of premium flower strains, concentrates and extracts, topicals, tinctures, vape and CBD products. Our knowledgeable patient care specialists are here to answer your questions and are committed to helping you find the right products for your medical needs. We offer the convenience of online ordering and in-store pickup for our guests who are pressed for time or do not want to shop in store, and we accept cash and debit cards.

Since opening in November of 2020, Ayr Wellness Medical Marijuana Dispensary New Castle has been proud to serve medical cannabis patients in Lawrence County to include the communities of Bessemer, Big Beaver, Campbell, Darlington, East Palestine, Edinburg, Ellwood City, Enon Valley, Evans City, Fombell, Grove City, Harmony, Hillsville, Hubbard, Koppel, Lowellville, Negley, New Bedford, New Castle, New Galilee, New Middletown, New Springfield, New Wilmington, Petersburg, Portersville, Prospect, Pulaski, Rogers, Slippery Rock, Struthers, Vienna Center, Villa Maria, Volant, Wampum, West Middlesex, West Pittsburg, Wheatland, Zelienople and the surrounding and the surrounding areas. 

Not a Medical Marijuana Patient?

Ayr Wellness New Castle is proud to partner with NuggMD to provide new patients and patients due for renewal the best resources to register for access to medical cannabis.
Learn More

New patients are eligible to receive exclusive discounts when shopping at our dispensary. Ask our patient care specialists for details!


Read Reviews About Our Cannabis Dispensary

“This dispensary rocks! The staff are super friendly and knowledgeable. Unlike its competition, there is some kind of a discount or sale daily. Also, I find the prices in general are also cheaper. Kudos on recognizing military veterans with a discount as well!” - Sean, Google User


“Great dispensary, with decent prices and wonderful staff!” - Scott, Google User


“I was very ambivalent going into Ayr Wellness the first time, right after I received my card. I had absolutely NO IDEA what to expect. After I completed the introductory paperwork and had my temperature taken, I was encouraged to enter "the inner sanctum," the place where the products are kept. I know virtually NOTHING about these products, but I DID know what I was in need of - PAIN RELIEF (broken ribs and spinal fracture, not good). The concierge took me under her wing and explained things thoroughly and methodically. She suggested products that would specifically target the type of pain that I'm having, and for once, I enjoyed my evening instead of being curled in a pain-ball on the heating pad!! I HIGHLY recommend Ayr Wellness. The only item on my "Ayr wish list" is THC patches. Hint, hint, owners. I think you'd do brisk business on them if you ordered in patches, even for a trial!!” - Jessamyn, Google User


“What an amazing location. The staff is super friendly and knowledgeable, and they have the best products around! I have a feeling I’ll be returning to this dispensary very often.” - Nick, Google User


“Absolutely amazing, knowledgeable staff! Also, they have quite the variety of flower and other products! Very friendly and welcoming environment! Highly recommend!” - Nicole, Google User


“People are so friendly and very welcoming! Great customer service and the atmosphere of the place is awesome, Highly recommend this place.” - Fampieca, Google User